American Chemical Society
Central Ohio Valley Section
Tuesday, November 3
Room 465 Science
Dr. Bo Li
Department of Chemistry
University of North Carolina-Chapel Hill
Chapel Hill, NC
"Chemical Mechanisms in the Biosynthesis and Action of Microbial Antibiotics"
Natural products and derivatives constitute a large fraction of modern medicine, especially in the area of antimicrobial therapy. Understanding how these compounds are synthesized in Nature is critical for the discovery and design of new natural products, to combat the rising multi-drug resistant infections. In this talk I will discuss our ongoing efforts to decipher the genetic basis and chemical logic in the biosynthesis of two classes of broad-spectrum antibiotics, including a naturally occurring hybrid molecule containing two antimicrobial warheads. In addition, I will describe our investigations of the redox chemistry of these natural products using a combination of biochemical, metabolomics and chemical genomic approaches, which revealed novel antimicrobial mechanisms of action.
Beijing University, B.S. , 2004; The University of Illinois at Urbana-Champaign, Ph.D., 2009; Jane Coffin Child Memorial Fund Postdoctoral Fellow, Harvard Medical School, 2009-2013; Visiting Scholar, John Innes Centre, UK, Summer 2011; Assistant Professor, University of North Carolina at Chapel Hill, 2013 - present
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